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Gastric Ulcers in Horses: Injectable Treatment in Development

The effects of equine gastric ulcer syndrome (EGUS) keep many horses from performing their best. Greater awareness of this has led horse owners to be more conscientious of management practices that optimize gastric health, including the use of FDA-approved treatments such as omeprazole and research-based nutritional supplements such as Rite-Trac.

A buildup of acid that is not buffered by saliva and feedstuffs can cause the development of gastric ulcers in horses which, in turn, can account for many roadblocks to well-being, such as inappetence, weight loss, dull coat, and sour disposition. A recent study* in Australia has suggested that a long-acting, intramuscular formulation of omeprazole (LA-OMEP) may suppress gastric acid for up to a week after administration.

Using 26 mature Thoroughbreds with known squamous and/or glandular gastric ulcers based on endoscopic examination, researchers administered 2 g of LA-OMEP (100 mg/ml) by intramuscular injection on day 0 and then again on day 7. Gastroscopy was performed on day 14 to determine the efficacy of LA-OMEP.

Gastroscopy revealed healing in all horses with squamous disease and 75% of horses with glandular disease, though improvement was noted in all lesions by at least one grade. No lesions in any of the horses appeared worse after treatment.

The researchers noted that the small sample size was a limiting factor in the study, but concluded that “the results of the present study compare favorably for the clinical outcomes of trials reporting the response to oral omeprazole therapy.”

“While injectable omeprazole is not yet available to horse owners, well-researched nutritional supplements, such as Rite-Trac, may stave off development of ulcers,” said Catherine Whitehouse, M.S., a nutrition advisor for Kentucky Equine Research (KER).

RiteTrac is a proprietary blend of ingredients designed to support total digestive tract health. Targeted to benefit the stomach and the hindgut of the horse, RiteTrac works in two distinct ways. First, with its combination of fast-acting antacids and coating agents, RiteTrac quickly neutralizes excess gastric acid, protecting the stomach lining and restoring the normal gastric environment. Second, RiteTrac contains EquiShure, a time-released hindgut buffer designed to act in the cecum and colon by maintaining optimal pH, thereby reducing the risk of hindgut acidosis.

For horse owners in Australia, look for these effective products.

*Sykes, B.W., K. Kathawala, Y. Song, S. Garg, S.W. Page, C. Underwood, and P.C. Mills. 2017. Preliminary investigations into the novel, long-acting, injectable, intramuscular formulation of omeprazole in the horse. Equine Veterinary Journal. In press.

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Nutrition (7)

Vitamins for Bone Health in Horses


Young horses require vitamins for growth. Some vitamins must be provided nutritionally, while others can be synthesized by the healthy individual. While vitamin D gets the lion’s share of attention for skeletal contributions, other vitamins are just as important, including vitamins A, C, and K.

Vitamin A has a distinct role in equine growth with both deficiency and toxicity of vitamin A adversely affecting growth, body weight, and rate of gain in young growing horses. “In the growing horse, vitamin A supports the proper functioning of osteoclasts, or bone-resorbing cells, during bone remodeling,” said Catherine Whitehouse, M.S., a nutrition advisor for Kentucky Equine Research (KER). “There is limited information on absolute vitamin A requirements for growing horses, but for horses grazing sufficient quantities of green pastures, vitamin A requirement can be met entirely by the carotenes in the forage.”..
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Exploring Aloe Vera for Equine Gastric Ulcers


In the seemingly never-ending battle against equine gastric ulcers, a research team from the University of Adelaide in South Australia reached for an unusual solution: aloe vera. According to those scientists*, aloe vera isn’t just soothing for burnt or irritated skin but also potentially beneficial for protecting the sensitive lining of the stomach.

“The inner leaf gel of the aloe vera plant has been reported to be effective in the prevention and treatment of gastric ulcers in man and in animals in experimental models. Its anti-ulcer properties have been attributed to a variety of possible mechanisms, including anti-oxidant activity, anti-inflammatory properties, cytoprotective and mucus-stimulatory effects, and its ability to regulate gastric acid production,” explained the researchers...
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Water-Soluble Vitamin E for Horses Proven Superior


Vitamin E (alpha-tocopherol) supplementation helps prevent various disorders affecting both the nervous and musculoskeletal systems, including neuroaxonal dystrophy/equine degenerative myeloencephalopathy, equine motor neuron disease, vitamin E deficient myopathy, and nutritional myodegeneration. These conditions can be prevented largely by providing adequate dietary vitamin E to horses, and recent research shows* that a liquid vitamin E supplement may be more beneficial than a powdered formulation.

“The current recommended daily dietary intake of vitamin E for adult horses is 1-2 IU/kg. Many horses obtain adequate vitamin E from pasture. When horses have limited access to pasture, either due to an underlying metabolic condition or during times of drought, and are instead offered hay, vitamin E levels may be depleted. In such cases, vitamin E supplementation could prove beneficial,” explained Kathleen Crandell, Ph.D., a nutritionist for Kentucky Equine Research (KER)...
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Electrolytes Vital for Performance Horses


More than one horse owner has asked herself this simple question, “Why don’t feed manufacturers put electrolytes in feed specifically designed for performance horses?” According to Joe Pagan, Ph.D., founder and owner of Kentucky Equine Research (KER), this is a reasonable question but one that is easily answered.

“A horse's energy requirement stays the same during consistent work,” explained Pagan, “but sweat losses change with weather, work intensity, and other factors. Horse owners need to be able to easily adjust the amount of electrolyte given based on sweat production.”..
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Changes in Horse Manure Consistency


Loose manure and diarrhea in horses typically stem from one of three causes: antibiotic therapy, diet, or disease. Because of excessive water loss associated with diarrhea, affected horses can become dehydrated and have other problems, so horse owners should investigate changes in manure consistency immediately, calling in a veterinarian if necessary.

Antibiotics are a well-known trigger for loose manure because they eliminate many of the innate and beneficial microorganisms that reside in the horse’s hindgut...
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Microbiota of the Neonatal Foal


During the first few weeks of a foal’s life, the development of a diverse and healthy microbiota occurs. The microbiota, or population of beneficial microorganisms such as bacteria and protozoa, plays a major role in the proper function of the immune system and will serve to protect the foal from harmful pathogens as it matures. The microbial population is influenced by environment and diet. Most discussion surrounding the equine microbiota involves mature horses, and a closer look at a foal’s hindgut inhabitants provides interesting insight.

Foals are born with a sterile gut, but microbial colonization begins the first day of life. Some researchers found that meconium, the foal’s first feces after birth, is not sterile, while others report that it is. Differences may be attributed to the mare or sample collection techniques...
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Maximizing Equine Health, Welfare Using GPS


Other than discretely observing your herd for hours on end in the rain, sleet, snow, or blistering heat at various hours of the day or night, how can you know if your horses are truly getting all the care they need? According to a group of Japanese researchers*, affixing global positioning system (GPS) units to halters of horses and tracking their movement generates important information for managing herds of all shapes, sizes, and compositions.

For example, the researchers used GPS units on mare-and-foal pairs to determine mare-foal, mare-mare, and foal-foal distances to better understand behaviors of broodmares. They found during the first month of age, dam–dam and foal–foal distances were significantly greater than dam–foal distances. This finding makes sense considering how frequently foals nurse during their first month of life. During the second month of age, the dam–foal distance increased, and by the sixth month of age, dam–foal distances were significantly greater than foal–foal distances.  ..
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Overweight Horses: How Much Hay Is Too Little?


To some horse owners, maintaining easy keepers on an appropriate diet requires incredible restraint. While owners may wish to turn their horses out in bountiful pastures, they know it’s best to limit intake and use the drylot or grazing muzzle instead. Likewise, caretakers who want to dish out just a few pounds of sweet feed refrain from doing so and offer a balancer pellet in lieu. When it comes to hay, these same horse owners know too much is not helpful, but how much is too little?

With a limited menu available for overweight horses, maximizing hay intake is important, said Catherine Whitehouse, M.S., a nutrition advisor with Kentucky Equine Research (KER). “Hay intake should be about 2% of body weight, if horses are receiving no other feed or forage.”..
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Metabolic Syndrome in Horses: Use of Sweeteners Studied


Despite best efforts by owners to follow strict diet recommendations for horses with metabolic syndrome, some feeds and medications contain sweeteners, including certain medications used to counteract equine metabolic syndrome (EMS).

Horses with EMS are insensitive to the effects of insulin, typically overweight, and may suffer chronic bouts of potentially life-threatening laminitis...
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Research on Algae for Horses with Ulcers


Treatment options and management strategies to help horses fight or prevent stomach ulcers exist, yet the ideal solution to ridding horses of these uncomfortable, niggling nuisances remains elusive. Could a high-algae supplement finally be the reprieve horse owners are looking for?

“Current options for handling ulcers, widely referred to as equine gastric ulcer syndrome or EGUS, include pharmaceutical drug administration, such as FDA-approved omeprazole products, nutritional supplements, and management changes,” remarked Kathleen Crandell, Ph.D., a Kentucky Equine Research (KER) nutritionist...
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Five Tips for Avoiding Pasture-Associated Laminitis in Horses


Scores of horses will gorge themselves on that long-awaited lush, green pasture of springtime. As many of us already know, overgrazing grasses and legumes that are high in water-soluble carbohydrates puts horses at risk for laminitis—a painful, life-threatening condition of the hooves.

“Many horse owners are already aware that pasture-associated laminitis is particularly concerning for overweight horses and ponies, easy keepers, those with insulin resistance or equine metabolic syndrome, and horses and ponies with a history of chronic laminitis. It is important for owners to appreciate, however, that pasture turnout can trigger a bout of laminitis even in lean, nonobese horses with no history of laminitis,” says Peter Huntington, B.V.Sc., M.A.C.V.Sc., director of nutrition at KER Australia. ..
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